These profiles specify how Mac key combinations and mouse shortcuts are mapped to shortcuts on a virtual machine, including key combinations for Windows 8 shortcuts.
With keyboard and mouse profiles, you can also specify whether keyboard shortcuts are sent to your Mac instead of the virtual machine, and you can specify which Fusion-specific keyboard shortcuts to enable.
Although you can also create and edit keyboard and mouse profiles in Fusion preferences, you use virtual machine settings to select which profile to use for a particular virtual machine.
You can edit the default profiles provided by Fusion, or you can create additional profiles, either by adding a new one or by duplicating and editing one of the existing profiles.